CYPROHEPTADINE

Drug Info

• Common Name: Periactin®
• Drug Type: Antihistamine
• Used For: Appetite stimulant in cats, Anti-serotonin agent, Cushing’s disease, Atopic dermatitis, Allergies
• Species: Dogs, Cats
• How Dispensed: Prescription only
• Available Forms: 4mg tablets
• FDA Approved: No

General Description

Cyproheptadine is an antihistamine that is commonly used in pets. It treats many symptoms, including allergies, loss of appetite, and increased serotonin production associated with Cushing’s disease. It does not treat the underlying problems causing these symptoms.

Along with its antihistamine effects, Cyproheptadine also works as an anti-serotonin agent. Serotonin is a neurotransmitter in the brain, and when it is suppressed, it leads to an increase in appetite. This is especially useful in cats undergoing chemotherapy, who tend to lose their appetite. Diseases such as Cushing’s lead to an increase in serotonin, so cyproheptadine may be used to reduce serotonin levels.

How It Works

Antihistamines counteract histamine, a chemical released to cause inflammation and itchiness as part of an allergic reaction. Cyproheptadine works by blocking H-1 receptors, which occur on the small blood vessels and smooth muscles. When histamine attaches to these receptors, it causes these vessels to widen, causing inflammation and itchiness and muscles around the airways to contract, which causes difficulty breathing.

Storage Information

Store in a tightly sealed container at room temperature.

Missed Dose?

Give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give your pet two doses at once.

Side Effects and Drug Reactions

Cyproheptadine may result in these side effects:

• Hyperexcitability in cats
• Dry mouth
• Increase heart rate
• Increase in appetite

Cyproheptadine may react with these drugs:

• Anticholinesterase
• Central Nervous System depressants
• Amitraz
• Furazolidone
• Selegiline

USE CAUTION WHEN ADMINISTERING THIS DRUG TO PETS WITH HEART FAILURE OR BLADDER DISORDERS

USE CAUTION WHEN ADMINISTERING THIS DRUG TO PREGNANT PETS