The veterinary FDA-approved product is labelled for “parenteral use in cows for the treatment of nymphomania (frequent or constant heat) due to cystic ovaries” and “as an aid in improving spawning function in male and female brood finfish.” 1 It has been used for other purposes in several species; refer to the Dosages section for more information.
Commonly used for used for a variety of theriogenology conditions in cattle, horses, dogs, cats, swine, sheep, goats and other species. 1
What is Pregnyl, and how is it used?
Pregnyl (chorionic gonadotropin) is a hormone used to cause ovulation and to treat infertility in women, and to increase sperm count in men. Human chorionic gonadotropin (HCG) is also used in young boys when their testicles have not dropped down into the scrotum normally. This can be caused by a pituitary gland disorder.
What are the side effects of Pregnyl?
Common side effects of Pregnyl include:
- swelling or water weight gain,
- breast tenderness or swelling, or
- injection site reactions (pain, swelling, or irritation).
Human chorionic gonadotropin (HCG), a polypeptide hormone produced by the human placenta, is composed of an alpha and a beta subunit. The alpha sub-unit is essentially identical to the alpha subunits of the human pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as to the alpha subunit of human thyroid-stimulating hormone (TSH). The beta subunits of these hormones differ in amino acid sequence.
PREGNYL® (chorionic gonadotropin for injection USP) is a highly purified pyrogen-free preparation obtained from the urine of pregnant females. It is standardized by a biological assay procedure. It is available for intramuscular injection in multiple dose vials containing 10,000 USP units of sterile dried powder with 5 mg monobasic sodium phosphate and 4.4 mg dibasic sodium phosphate. If required, pH is adjusted with sodium hydroxide and/or phosphoric acid. Each package also contains a 10-mL vial of solvent containing: water for injection with 0.56% sodium chloride and 0.9% BENZYL ALCOHOL, WHICH IS NOT FOR USE IN NEWBORNS. If required, pH is adjusted with sodium hydroxide and/or hydrochloric acid.