Selegiline is an oral prescription medication used to treat cognitive dysfunction and senility in older dogs.
It can also be used to treat Cushing’s disease when it is caused by a pituitary tumor. It’s a generic alternative to Anipryl, and it’s the only FDA-approved drug for canine senility. It comes in a capsule form, so you can easily hide it in a pill pocket and give it as a tasty treat or disguise it in your pal’s favorite wet food. Customers may receive this drug under the names l-deprenyl, Anipryl, Eldepryl.
- Treats Canine Cushing’s disease
- Treats age-related cognitive problems in older dogs
- for use in Dogs
How it works
Selegiline increases the concentration of a nervous system messenger chemical called dopamine. Higher levels of dopamine improve many cognitive processes. Treating Cushing’s Disease has traditionally been centered on suppressing the adrenal glands production and release of cortisone. However, this approach has a high potential for side effects. Selegiline has allowed for a new approach by suppressing the pituitary gland directly.
Selegiline hydrochloride capsules, USP are indicated as an adjunct in the management of Parkinsonian patients being treated with levodopa/carbidopa who exhibit deterioration in the quality of their response to this therapy. There is no evidence from controlled studies that selegiline has any beneficial effect in the absence of concurrent levodopa therapy.
Evidence supporting this claim was obtained in randomized controlled clinical investigations that compared the effects of added selegiline or placebo in patients receiving levodopa/carbidopa.
Selegiline was significantly superior to placebo on all three principal outcome measures employed: change from baseline in daily levodopa/carbidopa dose, the amount of off time, and patient self-rating of treatment success. Beneficial effects were also observed on other measures of treatment success (e.g., measures of reduced end of dose akinesia, decreased tremor and sialorrhea, improved speech and dressing ability and improved overall disability as assessed by walking and comparison to previous state).
Give this medication exactly as directed by your veterinarian. Allow pet to drink plenty of water. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Store selegiline at room temperature away from moisture and heat. Keep this medication away from children and pets.
Dogs: when used for cognitive dysfunction
The starting dose for canine cognitive dysfunction is 0.2mg-0.45mg per pound of pets body weight. It may take up to one month or more to see improvement.
Dogs: when used for Cushings disease
The usual starting dose to treat Cushings disease is 0.45mg per pound of pets body weight given once a day in the morning. If no result within two months, may increase to 0.9mg per pound of pets body weight. If still no response after one month of the increased dose, your pet should be reevaluated.
Selegiline is also used in dogs to treat canine cognitive dysfunction.
Do not give more of this medication than is prescribed without consulting your veterinarian.
Because Selegiline belongs to a class of drugs called Monoamine Oxidase Inhibitors MAOI it should not be given with antidepressants such as Prozac. Do not use in pregnant or nursing animals.
If any serious side effects occur difficulty breathing, hives, agitation, swelling of the lips, tongue or face, stop giving Selegiline and seek emergency veterinary medical attention. Make sure you tell your veterinarian what other medications you are giving your pet.
elegiline should not be given if the pet is taking meperidine.
Inform your veterinarian about any other medical conditions your pet has.
Inform your veterinarian if your pet is pregnant or lactating.
Keep this medication away from children and pets. et.Selegiline may cause dizziness or drowsiness. Do not give higher doses than those prescribed.
Do not use in breeding, pregnant, or lactating animals (female dogs nursing puppies); the safety of the drug has not been determined in these animals. Do not use this medication for the treatment of aggression.
Store at room temperature in a light resistant container.
Possible Drug Interactions:
Discuss with your veterinarian if your pet is also taking fluoxetine or meperidine. Talk to your veterinarian or pharmacist before giving any prescription or over the counter medicines.
Possible Side Effects:
If any of the following serious side effects occur, stop giving selegiline and seek emergency veterinary medical attention an allergic reaction difficulty breathing swelling of the lips, tongue or face hives, a severe headache, restlessness, agitation, or irritability, sweating, convulsions, uncontrollable or irregular movements.
Other less serious side effects may occur. Continue giving selegiline and talk to your veterinarian if your pet develops dizziness or drowsiness, nausea, abdominal pain or diarrhea, insomnia, mild confusion, agitation or anxiety, dry mouth. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal.